Generally emulsions are water-in-oil or oil-in-water type, but emulsions may contain polar liquid as one of the phase. Non-aqueous emulsions are useful in many situations where presence of water is not desirable, formulation of active ingredients which undergo hydrolysis or oxidation in presence of water. The study was to design a stable non-aqueous microemulsion using cosmetically approved ingredients as a vehicle for the water sensitive active ingredients. Non aqueous microemulsions were designed to increase the dermal penetration and permeation and study solubility and dermal bioavailability of griseofulvin. For better compliance incorporated the non aqueous micro emulsions in cosmetics or personal care products. A non-aqueous system was obtained with glycerin and olive oil stabilized by glycerol monosterate with cosurfactant. It was observed that emulsification behavior is completely unpredictable and conventional theories of emulsification and HLB system cannot be applied here. An optimized non-aqueous microemulsion was obtained through implementation of pseudo ternary phase diagram. Pseudo ternary phase diagram was constructed using surfactant and co surfactant ratio (1:1, 2:1, 3:1, 4:1) and microemulsion region was determined and further characterized for pH, rheology, spreadability, drug content, globule size analysis, zeta potential and stability. In-vitro drug release shows increases permeation rate compared to aqueous formulation. Stability studies (agitation, centrifugation, freeze thaw cycle, accelerated stability) were carried out at 5°C, 25°C and 40°C. Cream was stable at 5°C and 25°C. Formulation was evaluated for antifungal activity against Microsporum gypsum and skin irritation test on mice skin. The result was significant and p value of all response for skin irritation was found to be ≤0.05. Results proved that non-aqueous micro emulsion can be used as vehicle for the poorly water soluble drug, suspension vehicles and oleogels.
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